What is the key principle of high value prescribing?

• A. Every med must have clear indication
• B. Prescribe as many generics as possible
• C. Avoid any combination therapy
• D. Use the newest medication

Answer: (A)

The main idea is that every medication should have a clear indication. In high value prescribing, each drug must have a specific, evidence-based reason for use that matches the patient’s condition, goals, and safety profile. This keeps the regimen intentional rather than adding drugs haphazardly, which reduces polypharmacy, lowers the risk of adverse effects and drug interactions, and uses resources wisely.

Generics can help reduce cost and are appropriate when they provide the same benefit, but that alone isn’t the defining principle. Using the newest medication isn’t automatically better and can drive up costs without added value. Combination therapy isn’t inherently wrong—some situations truly require multiple agents—but it should be chosen only when there is a clear indication and net benefit.